3,3-Dimethyl-1-butanol is an organic compound (amyl alcohol) and a structural analog of choline.
DMB inhibits formation of microbial trimethylamine (TMA) in mice (e.g., from bacteroidetes bacteria Proteus mirabilis) and in human feces, It thereby reduces plasma levels of trimethylamine N-oxide (TMAO) after choline or carnitine supplementation.
While mice placed on a choline supplemented diet showed an increase in the proportions of Clostridiales (Firmicutes including pathogens), DMB induced a decrease in the proportions of these bacteria.
DMB is found in some cold-pressed extra virgin olive oils, grapeseed oils, balsamic vinegars, and red wines. It has pheromone-like properties attracting female sap-sucking insects.
It has been shown that blocking diet-induced atherosclerosis at the host level can be done by genetically knocking down flavin-containing monooxygenase 3 (FMO3), but that results in the fish malodor syndrome (TMAU). There’s growing appreciation that inhibition of microbial formation of TMA (and thus of TMAO) may be a better way of treating heart disease.
DMB inhibits formation of microbial trimethylamine (TMA) in mice (e.g., from bacteroidetes bacteria Proteus mirabilis) and in human feces, It thereby reduces plasma levels of trimethylamine N-oxide (TMAO) after choline or carnitine supplementation.
While mice placed on a choline supplemented diet showed an increase in the proportions of Clostridiales (Firmicutes including pathogens), DMB induced a decrease in the proportions of these bacteria.
DMB is found in some cold-pressed extra virgin olive oils, grapeseed oils, balsamic vinegars, and red wines. It has pheromone-like properties attracting female sap-sucking insects.
It has been shown that blocking diet-induced atherosclerosis at the host level can be done by genetically knocking down flavin-containing monooxygenase 3 (FMO3), but that results in the fish malodor syndrome (TMAU). There’s growing appreciation that inhibition of microbial formation of TMA (and thus of TMAO) may be a better way of treating heart disease.
References
Wang, Zeneng; Roberts, Adam B.; Buffa, Jennifer A.; Levison, Bruce S.; Zhu, Weifei; Org, Elin; Gu, Xiaodong; Huang, Ying; Zamanian-Daryoush, Maryam; Culley, Miranda K.; DiDonato, Anthony J.; Fu, Xiaoming; Hazen, Jennie E.; Krajcik, Daniel; DiDonato, Joseph A.; Lusis, Aldons J.; Hazen, Stanley L. (December 2015). "Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis". Cell 163 (7): 1585–1595. doi:10.1016/j.cell.2015.11.055.
Wang, Zeneng; Roberts, Adam B.; Buffa, Jennifer A.; Levison, Bruce S.; Zhu, Weifei; Org, Elin; Gu, Xiaodong; Huang, Ying; Zamanian-Daryoush, Maryam; Culley, Miranda K.; DiDonato, Anthony J.; Fu, Xiaoming; Hazen, Jennie E.; Krajcik, Daniel; DiDonato, Joseph A.; Lusis, Aldons J.; Hazen, Stanley L. (December 2015). "Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis". Cell 163 (7): 1585–1595. doi:10.1016/j.cell.2015.11.055.
