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AURAMETRIX

Microbes of anti-social odor

11 Comments

 
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Human odors depend on many extrinsic (such as food or clothing) and intrinsic factors - localized or systemic. 

In recent years, microbes responsible for localized malodors - bad breath caused by oral bacteria and axillary odor - have been mapped using next generation sequencing approaches. However, Intestinal microbes responsible for systemic malodor (whole-body and extraoral halitosis), remain to be identified.

Our preliminary analysis of culture-, PCR- and 16S-RNA-based data donated by MEBO and PATM community members show that there are no easy answers. 

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"Lower Firmicutes to get firm and cute," says a news headline. MEBO population is low in Firmicutes and higher in Bacteroidetes. ​In fact, the very low F/B ratio is just about the only thing in common across the population in the Genova PCR-based microbiome analyses. The figure above shows typical representatives of MEBO "sweet" (on the left) and "non-sweet" (on the right) groups, as defined in our previous posts, video presentations and reports.  

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uBiome data, including SmartGut and Explorer, shows that MEBO community doesn't really have too many smellier bacteria, and likely has lower trimethylamine-producing potential than the average population.  Many odoriferous bacteria  - such as Odoribacter (ammonia odor), B. crossotus (rancid butter) and Desulfovibrio piger​ (rotten eggs) are often low in numbers, in at least one of the tests for every participant.  But the composition of "scent tones" differs from normal. 

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This phylogenetic tree shows some of the bacteria found in abnormal levels in the MEBO community (underlined). Other bacteria displayed were found to cause (red) or compensate for (green) halitosis and underarm odors. TMA- and/or sulfide-producers are shown in brown. Some of them - like Staphylococcus hominis  - produce additional volatiles like thioalcohols responsible for the characteristic unpleasant body odor smell. As seen from the figure, many bacteria can be either good or bad smell-wise on species level. This means that our 16S-RNA-based data doesn't always have sufficient resolution and might not adequately uncover the odor-producing potential.

Our preliminary findings show that "sweet" group of MEBO community  is high in Anaerotruncus colihominis - indole (fecal smell) producing bacteria that utilises sugars glucose and mannose. Everyone seems to be low in Ruminococcus albus  - a primary cellulose degrader that produces hydrogen and sweet-smelling acetate.  ​60% are low in Oxalobacter formigenes. Many participants had higher levels of Proteobacteria - but everyone had their own species - such as E.coli, Citrobacter freundii, Enterobacter Cloacae,  Klebsiella or Aggregatibacter. Butyric acid-producing Butyrivibrio crossotus was abnormal in all of our samples: either too high or (mostly) too low. We also observed cases when the gut microbiota was significantly unstable  - similar to Crohn's disease (even when patients are in remission).

We owe much of our general good health to the results of bacterial wars when the "good" species are destroying the "bad" invaders. Could it be that systemic malodor arises from bacterial wars that have no real purpose? Our research is only just beginning. 
​

11 Comments
Muhammad Ali
3/15/2018 04:19:51 am

Maybe You are near about finding the cause . I took high doses of Medicines specially Anti-bacterials and many others. I have been thinking about it that it is due to Killing of Good Bacteria too with Bad bacteria while taking medicines after surgery . Then Fungus( yeast like ) appeared on Scalp . Which went away after applying Salicyclic Acid and others . Initially I was having Symptoms of TMAU . Bad smell specially from exhaled air , mouth , Haliotosis too . Visiting 5-6 best doctors taking further medicines Smell reduced but Symptoms of PATM appeared badly.

Reply
Irene Gabashvili link
3/15/2018 07:17:26 pm

Antibiotics alter the balance of the microbial community. Improving gut microbial balance is the key. Resveratrol could help those with low Bifidobacterium and Lactobacillus counts and high Clostridia. However, Resveratrol Supplement with Quercetin could decrease Butyrivibrio Crossotus. If it is low, Grape Seed extract, Walnuts and
Saccharomyces boulardii seemed to be helpful. Many PATM sufferers said Saccharomyces boulardii helped relieve their symptoms.

Reply
Muhammad Ali
3/16/2018 10:02:15 am

Thanks Dr. Irene ...
If you have any update about relieving symptoms of PATM Please share it on MEBO facebook page in PATM/TMAU group.....
Will be thankful to you for thiis....

NK link
3/16/2018 12:00:11 am

Could you also publish finding to curate the bacteria war fare.. A smilar mapping to the chart above including how to manage high/low range of imbance w.r.t each of the bacteria found above. Will really help as otherwise need to research each one separately then pray that hit an trial works in favour...

Reply
Irene Gabashvili
3/16/2018 12:13:54 pm

I will compile a chart for MEBO annual meeting and publish it here.

Reply
NK
3/16/2018 12:25:50 pm

Thanks Dr. Irene ... This above compilation of yours is a huge help to so many sufferers. Can not thank enough. God bless.

Aa
8/18/2019 09:57:14 pm

Please let me also know new updates for tmau pill that will be release 2010-2023 but i hope the sooner the better.. and i hope its over the counter here in winnipeg canada, and not too expensive. I hope my body odor will not come back. Do 8 have to take it for a lifetime?

Thank u

Michael Haram
3/17/2018 08:45:49 am

Thanks for great job. We are still waiting for radical solutions

Reply
Wanda edwards
3/17/2018 05:58:38 pm

Yes....i really do think its a gut thing...yrs ago i really did abuse antibiotics..pain killers...etc...

Reply
Roni
5/1/2018 08:15:54 am

how do i join this forum...i clicked this under someone else

Reply
Joe link
9/16/2020 05:40:16 pm

I have PATM and I believe I have ammonia in my sweat making people sneeze, sniff etc. People say it smells bad sometimes. I have seen doctors and therapist but it seems they avoid it and say i am crazy. I need a cure ASAP, it began at puberty. Thank You

Reply



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