For perindopril as treatment for hypertension, the initial dose is 5 mg perindopril arginine (or 4 mg perindopril erbumine) once daily, then the dose may be increased to 10 mg perindopril arginine (or 8 mg perindopril erbumine) after one month of treatment to improve blood pressure control or in case of concomitant stable coronary artery disease.
The Anglo-Scandinavian Cardiac Outcomes Trial showed the benefits of taking the two drugs perindopril and amlodipine together.
SEVERE side effects occur: severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, eyes, throat, or tongue; hoarseness); chest pain; confusion; decreased, difficult, or painful urination; depression; difficulty swallowing; fast, slow, or irregular heartbeat; fever, chills, or sore throat; numbness of an arm or leg; one-sided weakness; prolonged or severe nausea, vomiting, or diarrhea; stomach pain (with or without nausea or vomiting); sudden, severe headache; swelling of the hands, legs, or trunk; symptoms of liver problems (e.g., dark urine, loss of appetite, pale stools, yellowing of the skin or eyes); symptoms of low blood pressure (eg, fainting, severe dizziness, light-headedness); unusual tiredness or weakness; vision or speech problems.